3D Bioprinting of Multicellular Constructs for the Development of Vascularized Skin Grafts
Internship Description
Workshop Description
3D bioprinting
technology has gained significant interest in biomedical engineering and
regenerative medicine applications. However, current 3D bioprinting
technologies utilize animal-based, plant-based, or synthetic polymer bioinks,
which lowers biocompatibility with the patient. Additionally, the existing
bioprinters use UV light or chemical treatment to polymerize the inks to form
gels, which may cause unwanted mutations and faulty expressions of genes within
the printed cells. The Laboratory for Nanomedicine at KAUST has developed a new
technique which combines peptide-based bioinks and a robotic arm-based system
for 3D bioprinting under true physiological conditions without any use of harsh
physico-chemical methods. This project involves the development of vascularized
skin grafts via 3D bioprinting of multicellular constructs for applications in
the diabetic wound healing. Ultrashort peptide bioinks will be used as
scaffolds for 3D bioprinting of human skin grafts.
Deliverables/Expectations
Deliverables
Mastering 3D
bioprinting using a commercial and a newly developed robotic 3D bioprinter
(Hauser), Computational analysis of 3D bioprinting efficiency (Michels),
creation of peptide bioinks (Hauser), developing skin grafts as a multicellular
construct
Faculty Name
Dominik L Michels
Field of Study
Field Of Study
3D bioprinting,
biomedical engineering, tissue engineering, regenerative medicine, vascularized
skin grafts