Lactate signaling in synaptic plasticity

Lactate signaling in synaptic plasticity

Internship Description

Our lab is interested in understanding the signaling and metabolic interplay taking place between neurons and supporting glial cells during normal brain functions and in neurodegeneration. Neurons expend a considerable amount of energy on neurotransmission while glia cells provide neurons with metabolic substrates, antioxidants and trophic factors. In addition to its role as an astrocyte-derived metabolite fueling the needs of active neurons, lactate has recently emerged as a signaling molecule in the brain.
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Deliverables/Expectations

The student will learn to prepare, transfect and maintain HEK293 cells and primary cultures of neurons. She or he will also develop PLAs and use fluorescent microscopy to study the signaling role of lactate in the potentiation of NMDA receptors in neurons and in HEK293 cells expressing wild-type and/or mutant CaMKII/NMDA receptors​

Faculty Name

Pierre Magistretti

Student Monthly Allowance

$1,000.00

Field of Study

Neurobiology, Cell Biology