Lactate signaling in synaptic plasticity
Internship Description
Workshop Description
Our lab is interested in
understanding the signaling and metabolic interplay taking place between
neurons and supporting glial cells during normal brain functions and in
neurodegeneration. Neurons expend a considerable amount of energy on
neurotransmission while glia cells provide neurons with metabolic substrates,
antioxidants and trophic factors. In addition to its role as an
astrocyte-derived metabolite fueling the needs of active neurons, lactate has
recently emerged as a signaling molecule in the brain.
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Deliverables/Expectations
Deliverables
The student will learn to
prepare, transfect and maintain HEK293 cells and primary cultures of neurons.
She or he will also develop PLAs and use fluorescent microscopy to study the
signaling role of lactate in the potentiation of NMDA receptors in neurons and
in HEK293 cells expressing wild-type and/or mutant CaMKII/NMDA receptors
Faculty Name
Pierre Magistretti
Student Monthly Allowance
$1,000.00
Field of Study
Field Of Study
Neurobiology, Cell Biology