Internship Description
Workshop Description
Advances in gene sequencing
have led to the production of a wealth of data linking gene mutations to
patient phenotypes. Structural biology can often reveal the underlying
molecular basis of a particular protein mutation but existing tools only look
at one gene at the time. This project aims at producing a software tool that
allows performing this structure-function analysis on a large scale and thus to
analyze structural mechanisms of diseases from big data resources.
Deliverables/Expectations
Deliverables
Creation
of several modules to compute/retrieve sequence-and structure-based properties
and integrate them in 3D (structure) space;
Conversion and cleanup of high-quality human mutation data from clinical
collaborator; Integration and correlation of both.